Focal brain metabolic effects detected by proton magnetic resonance spectroscopy (MRS) in obsessive-compulsive disorder (OCD) represent prospective indices of clinical status and guides to treatment design. Sampling bilateral pregenual anterior cingulate cortex (pACC), anterior middle cingulate cortex (aMCC), and thalamus in 40 adult patients and 16 healthy controls, we examined relationships of the neurometabolites glutamate+glutamine (Glx), creatine+phosphocreatine (Cr), and choline-compounds (Cho) with OCD diagnosis and multiple symptom types. The latter included OC core symptoms (Yale-Brown Obsessive-Compulsive Scale - YBOCS), depressive symptoms (...) (Montgomery-Åsberg Depression Rating Scale - MADRS), and general functioning (Global Assessment Scale - GAS). pACC Glx was 9.7% higher in patients than controls. Within patients, Cr and Cho correlated negatively with YBOCS and MADRS, while Cr correlated positively with the GAS. In aMCC, Cr and Cho correlated negatively with MADRS, while Cr in thalamus correlated positively with GAS. These findings present moderate support for glutamatergic and cingulocentric perspectives on OCD. Based on our prior metabolic model of OCD, we offer one possible interpretation of these group and correlational effects as consequences of a corticothalamic state of elevated glutamatergic receptor activity alongside below-normal glutamatergic transporter activity. (shrink)

The present study examines the comorbidity between specific learning disorders and attention deficit and hyperactivity disorder by comparing the neuropsychological profiles of children with and without this comorbidity. Ninety-seven schoolchildren from 8 to 14 years old were tested: a clinical sample of 49 children with ADHD, SLD or SLD in comorbidity with ADHD, and 48 typically-developing children matched for age and intelligence. Participants were administered tasks and questionnaires to confirm their initial diagnosis, and a battery of executive function tasks testing (...) inhibition, shifting, and verbal and visuospatial updating. Using one-way ANOVAs, our results showed that all children in the clinical samples exhibited impairments on EF measures when compared with TD children. A more specific pattern only emerged for the updating tasks. Only children with SLD had significant impairment in verbal updating, whereas children with ADHD, and those with SLD in comorbidity with ADHD, had the worst performance in visuospatial updating. The clinical and educational implications of these findings are discussed. (shrink)

Metaphors abound in descriptions of the COVID-19 pandemic: it is described, among other things, as a war, a flood, and a marathon. However, not all metaphors may resonate equally well with members...

Une premisse majeure met en place les arguments les plus normatifs de la Republique : les caracteres des hommes sont la cause des caracteres des cites. Le gouvernement de Kallipolis est le meilleur de tous, explique Socrate, pour une raison tres simple : c’est le gouvernement des meilleurs. Dans une demokratia, en revanche, n’importe qui peut revetir un role de pouvoir par tirage au sort, et n’importe qui peut dire n’importe quoi. Tandis que les meilleurs des Gardiens se soucient du (...) bien politique au superlatif, le peuple n’en a cure. Il foule aux pieds l’idee meme qu’il faudrait choisir et eduquer les magistrats. Le Peuple ne saurait être philosophe. Et pourtant, à Athènes, la parole politique et le langage à l’oeuvre dans l’administration de la cite montrent une quete acharnee du mieux possible. Le temoignage epigraphique nous devoile une citee pavee de bonnes intentions, engagee dans un perfectionnisme democratique que Platon refuse de reconnaitre. (shrink)

L’objectif de cette étude est d’examiner l’hypothèse selon laquelle la quarta natura, théorisée par Épicure pour rendre compte des activités de l’âme et décrite par Lucrèce (DRN III, 237-244), résulte de l’appropriation par Épicure d’un argument aristotélicien afin de répondre aux critiques d’Aristote à l’égard de la théorie démocritéenne de l’âme. Pour ce faire, on analysera le témoignage de Cicéron (Tusc. I, 10, 22) sur le quintum genus attribué à Aristote et on rendra compte des débats sur ses sources possibles. (...) En confrontant le témoignage cicéronien avec les vers dans lesquels Lucrèce expose la théorie de la quatrième nature, on montrera les fortes ressemblances entre leurs structures argumentatives. Sur la base de la possible datation de la théorie de la quintessence et de son attribution au Péripatos du iie siècle av. J-C, on proposera d’expliquer cette similarité par l’appropriation par Lucrèce de l’argument par soustraction qui caractérise la théorie de la quintessence, à partir de laquelle il aurait conçu la théorie de la quatrième nature. Afin de vérifier l’exactitude de cette interprétation, on examinera l’hypothèse selon laquelle l’appropriation de cet argument, et donc la conception de la quatrième nature, remontent à Épicure, la paternité de l’argument par soustraction (à partir duquel les péripatéticiens postérieurs pourraient avoir conçu la théorie de la quintessence) étant alors à attribuer à Aristote. Pour ce faire, on analysera un passage du De Caelo (269a30-269b2) et un passage de La Génération des animaux (736b29-737a1) où l’argument par soustraction sert à introduire d’une part l’éther et d’autre par le pneuma. Ensuite, en s’appuyant sur l’analyse d’un passage du De Anima (405a5-7), on montrera que l’appropriation de cet argument pourrait s’expliquer par la tentative, de la part d’Épicure, de répondre à une critique aristotélicienne concernant la théorie démocritéenne de l’âme. (shrink)

Nel 2004, in occasione del secondo bicentenario della morte di Kant, i cartesiani tornarono nelle fila dell'interpretazione che Ferdinand Alquié aveva opposto a quella di Alexis Philolenko. È possibile indagare su “Descartes est en Kant” per il fatto che il filosofo di Konisberg, come Cartesio prima di lui, poneva l'essere al di là della conoscenza. Certamente il percorso seguito fu un altro: Kant lo fece ponendo la condizione dei limiti della conoscenza; Cartesio affermando il carattere incomprensibile dell'infinito. Inutile, tuttavia, cercare (...) citazioni da Cartesio in Kant Werke, ed è impossibile risalire a tesi o concetti di scrittura cartesiana che possano essere identificati come tali. Così, i cartesiani, nel 2004, cercavano ciò che c'è in “Descartes est en Kant” al di là del confronto tra dottrine isolate, poiché i testi non consentono di stabilire affiliazioni dirette (come volevano i neokantiani): l'affiliazione di Cartesio a Kant trova nella co-appartenenza dei due filosofi allo stesso orizzonte di problemi. Sulla scia di Alquié, l'obiettivo dei cartesiani era »finalement, de reconnaître dans quelle mesure Kant renouvelle le moment cartésien, en sorte que, lorsque Kant pense, Descartes s'avance encore, caché. Caché en Kant, agissant encore sous la figure de Kant». (shrink)

There is a debate about the measure of IQ in children with ADHD. Some studies report that, compared to static assessment procedures, dynamic assessment of intelligence can better measure cognitive modifiability and plasticity. The present study was designed to examine children belonging to different ADHD subtypes in terms of both static and dynamic measures. Thirty-four children were compared to a sample of 27 typically developing children. Results indicate that only the inattentive and the combined subtypes, compared with the normative sample, (...) show lower IQ scores. The ADHD-I group presents generally low WISC scores and ADHD-H presents generally high WISC scores. Moreover, the ADHD-C group shows a low static score and a high dynamic score, indicating a wide breadth of Vygotskian children’s zone of proximal development. Static and dynamic measurements together can indeed be considered a comprehensive examination of intelligence levels in ADHD children and may be essential in predicting learning capacities. (shrink)

In much of the current academic and public discussion, conspiracy theories are portrayed as a negative phenomenon, linked to misinformation, mistrust in experts and institutions, and political propaganda. Rather surprisingly, however, philosophers working on this topic have been reluctant to incorporate a negatively evaluative aspect when either analyzing or engineering the concept conspiracy theory. In this paper, we present empirical data on the nature of the concept conspiracy theory from five studies designed to test the existence, prevalence and exact form (...) of an evaluative dimension to the ordinary concept conspiracy theory. These results reveal that, while there is a descriptive concept of conspiracy theory, the predominant use of conspiracy theory is deeply evaluative, encoding information about epistemic deficiency and often also derogatory and disparaging information. On the basis of these results, we present a new strategy for engineering conspiracy theory to promote theoretical investigations and institutional discussions of this phenomenon. We argue for engineering conspiracy theory to encode an epistemic evaluation, and to introduce a descriptive expression—such as ‘conspiratorial explanation’—to refer to the purely descriptive concept conspiracy theory. (shrink)

In today’s pluralistic society, clinical ethics consultation cannot count on a pre-given set of rules and principles to be applied to a specific situation, because such an approach would deny the existence of different and divergent backgrounds by imposing a dogmatic and transcultural morality. Clinical ethics support (CES) needs to overcome this lack of foundations and conjugate the respect for the difference at stake with the necessity to find shared and workable solutions for ethical issues encountered in clinical practice. We (...) argue that a pragmatist approach to CES, based on the philosophical theories of William James, John Dewey, and Charles Sanders Peirce, can help to achieve the goal of reaching practical solutions for moral problems in the context of today’s clinical environment, characterized by ethical pluralism. In this article, we outline a pragmatist theoretical framework for CES. Furthermore, we will show that moral case deliberation, making use of the dilemma method, can be regarded an example of a pragmatist approach to CES. (shrink)

Teaching responsible conduct of research (RCR) to PhD students is crucial for fostering responsible research practice. In this paper, we show how the use of Moral Case Deliberation—a case reflection method used in the Amsterdam UMC RCR PhD course—is particularity valuable to address three goals of RCR education: (1) making students aware of, and internalize, RCR principles and values, (2) supporting reflection on good conduct in personal daily practice, and (3) developing students’ dialogical attitude and skills so that they can (...) deliberate on RCR issues when they arise. What makes this method relevant for RCR education is the focus on values and personal motivations, the structured reflection on real experiences and dilemmas and the cultivation of participants’ dialogical skills. During these structured conversations, students reflect on the personal motives that drive them to adhere to the principles of good science, thereby building connections between those principles and their personal values and motives. Moreover, by exploring personal questions and dilemmas related to RCR, they learn how to address these with colleagues and supervisors. The reflection on personal experiences with RCR issues and questions combined with the study of relevant normative frameworks, support students to act responsibly and to pursue RCR in their day-to-day research practice in spite of difficulties and external constraints. (shrink)

De Interpretatione is among Aristotle's most influential and widely read writings; C. W. A. Whitaker presents the first systematic study of this work, and offers a radical new view of its aims, its structure, and its place in Aristotle's system. He shows that De Interpretatione is not a disjointed essay on ill-connected subjects, as traditionally thought, but a highly organized and systematic treatise on logic, argument, and dialectic.

In this paper I would like to propose the notion of “affective artifact”, building on an analogy with theories of cognitive artifacts and referring to the development of a situated affective science. Affective artifacts are tentatively defined as objects that have the capacity to alter the affective condition of an agent, and that in some cases play an important role in defining that agent’s self. The notion of affective artifacts will be presented by means of examples supported by empirical findings, (...) by discussing a tentative definition and classification, and by considering several related but differing notions. Within the framework of situated affectivity, the notion of affective artifacts will represent a further step in the enterprise of understanding how the environment helps us scaffold our affective processes. I will conclude that affective artifacts play a key role in the philosophy of cognitive science, the philosophy of technology and in the debate about the self. (shrink)

Responses to the COVID-19 pandemic globally disrupted lives and contributed to the exacerbation of pre-existing inequalities. Women in research were also affected. The prominent role that women played in professional and personal care duties had a detrimental effect on their research outputs, potentially hindering their career progression. Moreover, the challenges faced by women academics during the pandemic, including job loss, increased mental health issues, and the intersection of gender with other socio-demographic traits exacerbated existing gender disparities within academia. By systematically (...) scoping the qualitative literature on the experiences of women researchers during the pandemic, this study sought to explore how women experienced and reacted to the challenges generated by the COVID-19 pandemic. A qualitative meta synthesis of the included studies revealed three themes: gendered professional expectations, colliding identities and coping strategies. These themes show how gendered roles such as teaching and professional care work, associated with the hierarchical and gendered division of tasks both at home and in the workplace, made women feel unsupported and alienated as relevant agents in the academic context. The study reveals the importance of pastoral care, teaching and service work as the essential backbone of the academic infrastructure, especially in times of crises. It also exposes how productivity-focused researcher assessment criteria, rewarding mainly individual results and unrewarding of care and service work, can be viewed as perpetuating structural inequalities based on gender, parenting situations, contractual situations and background. In conclusion, this study exposes the need to proactively address the gendered practices and implicit biases which reproduce inequalities within academia and highlights how paying attention to the experiences and needs of women researchers is essential for improving the resilience and crises preparedness of academic the system. (shrink)

What are conspiracy theories? And what, if anything, is epistemically wrong with them? I offer an account on which conspiracy theories are a unique way of holding a belief in a conspiracy. Specifically, I take conspiracy theories to be self-insulating beliefs in conspiracies. On this view, conspiracy theorists have their conspiratorial beliefs in a way that is immune to revision by counter-evidence. I argue that conspiracy theories are always irrational. Although conspiracy theories involve an expectation to encounter some seemingly disconfirming (...) evidence (allegedly planted by the conspirators), resistance to all counter- evidence cannot be justified on these grounds. (shrink)

BackgroundClinical ethics support aims to support health care professionals in dealing with ethical issues in clinical practice. Although the prevalence of CES is increasing, it does meet challenges and pressing questions regarding implementation and organization. In this paper we present a specific way of organizing CES, which we have called integrative CES, and argue that this approach meets some of the challenges regarding implementation and organization.MethodsThis integrative approach was developed in an iterative process, combining actual experiences in a case study (...) in which we offered CES to a team that provides transgender health care and reflecting on the theoretical underpinnings of our work stemming from pragmatism, hermeneutics and organizational and educational sciences.ResultsIn this paper we describe five key characteristics of an integrative approach to CES; 1. Positioning CES more within care practices, 2. Involving new perspectives, 3. Creating co-ownership of CES, 4. Paying attention to follow up, and 5. Developing innovative CES activities through an emerging design.ConclusionsIn the discussion we compare this approach to the integrated approach to CES developed in the US and the hub and spokes strategy developed in Canada. Furthermore, we reflect on how an integrative approach to CES can help to handle some of the challenges of current CES. (shrink)

In this paper, I argue that in the Eudemian Ethics, Aristotle proposes a strong version of the unity of the virtues. Evidence in favor of this strong version of the unity of the virtues results from reading the common books within the EE rather than as part of the Nicomachean Ethics. The unity of the virtues as defended in the EE includes not only practical wisdom and the character virtues, but also all the virtues of practical and theoretical thinking. Closely (...) related, in the EE, Aristotle proposes a different best agent from the one of the NE. The best agent of the EE is the kalos kagathos. The person who is kalos kagathos has “all” the virtues. Kalokagathia is a whole and the virtues are its parts. I investigate how we should understand this whole and the relation between the individual virtues within this whole. (shrink)

According to Smell Objectivism, the smells we perceive in olfactory experience are objective and independent of perceivers, their experiences, and their perceptual systems. Variations in how things smell to different perceivers or in different contexts raise a challenge to this view. In this paper, I offer an objectivist account of non-illusory contextual variation: cases where the same thing smells different in different contexts of perception and there is no good reason to appeal to misperception. My central example is that of (...) dihydromyrcenol, a substance that can smell both woody and citrusy depending on what other odourants one has recently been exposed to. I first argue that the subjects’ apparently conflicting reports about the way dihydromyrcenol smells are best understood as comparative characterisations of a smell. Given this understanding, different reports can be correctly made in response to perceiving the very same smell. I then argue that the phenomenal difference between the experiences subjects have across contexts can be explained compatibly with Smell Objectivism. On the account proposed, subjects perceive the very same smell but different qualities, notes, or aspects of it are salient to them, depending on the context of perception. I then consider how the proposed defence of Smell Objectivism can be adapted to other cases where the same thing is reported as smelling different in different contexts. (shrink)

This paper is dedicated to the relationship between ordinary moral thought and ethical theory in Sidgwick’s The Methods of Ethics. I suggest that different contents of ordinary moral thought play different roles and are lent different philosophical weight in Sidgwick’s arguments. I start by showing how Sidgwick appeals to certain features of ordinary moral thought, deduced from moral language and experience, both in criticising rival metaethical positions and in establishing his own claims. I then turn to the notion of common-sense (...) morality. After clarifying what Sidgwick means by this expression, I argue that common-sense morality has neither probative value in Sidgwick’s argument for the utilitarian principle nor independent validity, and that its authority is ultimately motivated on utilitarian grounds. Pointing out how different contents of ordinary moral thought play different argumentative roles in the foundation and defence of Sidgwick’s utilitarianism enables to ac- count more comprehensively for Sidgwick’s arguments and moral methodology and provides with a more articulated account of the dialectic between his utilitarian theory and ordinary moral thought. (shrink)

In connecting embodied, embedded, extended, and enactive (4E) cognition with affectivity and emotions, the framework of “situated affectivity” has recently emerged. This framework emphasizes the interactions between the emoter and the environment in the unfolding of our affective lives (Colombetti and Krueger 2015; Griffiths and Scarantino 2009; Piredda 2022; Stephan and Walter 2020). In the last decades, there has also been a growing interest in the philosophical analysis of technology and artifacts (Houkes and Vermaas 2010; Margolis and Laurence 2007; Preston (...) 2022). The aim of this special issue is to foster the interaction between philosophical reflections on affectivity and those on technology, further developing this fruitful borderland (Clowes et al. 2021; Colombetti 2020; Fasoli 2018; Krueger and Osler 2019; Heersmink 2018; Piredda and Candiotto 2019; Piredda 2020; Viola 2021). -/- . (shrink)

This paper is a contribution to the philosophical debate on visual blur from a relationalist perspective. At the same time, it offers a methodological reflection on the adequacy of explanations of phenomenal similarities and differences among perceptual experiences. The debate on seeing blurrily has been shaped by two implicit assumptions concerning our explanations of differences and similarities between experiences of seeing blurrily and other experiences. I call those assumptions into question, and argue that we do not need to provide a (...) unified explanation of the character of blurry experiences for our account to be adequate. The diversity of blurry experiences supports a different, pluralist approach to explanations of how things appear to subjects. (shrink)

For a long time, the accepted explanatory model of language acquisition was the so-called Principles and Parameters framework (P&P). P&P seemingly provides an elegant answer to the central puzzle of generative linguistics: How do children acquire their native language given the limited time and input resources available to them? Yet P&P tells a story that is evolutionarily implausible, and for this reason it has since been abandoned. I argue that this is an unwarranted move, and that it could and should (...) be avoided by reassessing the epistemic status of P&P. In particular, I argue that contrary to extant accounts, P&P ought to be retrospectively construed as a highly idealized (toy) model of language acquisition. The proposed reinterpretation is vindicated, I argue, insofar as it paves the way for a reconciliation of the two central explanatory challenges of modern generative linguistics. (shrink)

In this article, I aim to analyse the way in which Jan Patočka explores the being of the dead in his text “Phenomenology of life after death.” I wish to show that this seminal text offers the solution to three main difficulties regarding the being of the dead: those difficulties concern their form of being, their possibility to transform themselves and their ability to act. Following this analysis, I propose a three‑folded thesis: firstly, the being of the dead can be (...) grasped not only through privation but also through more positive forms; secondly, the dead persons can continue to transform themselves when being construed by the living; and thirdly, their action can be prolonged even though they cannot act. (shrink)

The contribution attests a research project coordinated by the Department of Human Sciences for Education “Riccardo Massa” and led in Mantova and Sabbioneta UNESCO sites. The project aims at accompanying citizens and visitors along a participative, sensorial and emotional path towards the cultural heritage’s enhancement and interpretation. Inspired by the desire to promote experiences helpful for an encounter between human beings and the environment, the body and the mind, the scientific and poetic dimension, we wanted to investigate and further explore (...) the possibility to plan and start exploratory itineraries and artistic-expressive-performing actions both for daily and one-day passers-by. These are meant to feel, to live and inhabit these places not only through a rational and intellectual awareness but, more importantly, through a bodily and emotional one. (shrink)

This article examines the role played by ‘feeling’ (Gefühl) and ‘love’ within the philosophy of German Romanticism. After an introduction (I) to the actual debate on German Romanticism, paragraph II sketches an analysis of the concept of Gefühl at the end of the eighteenth century and highlights the differences with its actual meaning. The successive three sections are dedicated to three pivotal figures of German Romanticism: F. Schlegel (III), Novalis (IV), and Baader (V). Similarities and differences between these authors will (...) be emphasized. It will be demonstrated that they deny the reason˗feeling opposition, and that ‘feeling’ and ‘love’ are at the heart of their ontology, epistemology, and conception of subjectivity, conditioning the Romantic human-nature relationship and Romantic political philosophy. In the concluding remarks (VI), this paper explains how German Romanticism can still help to better understand the role of feelings in politics. (shrink)

The asymptotic safety program strives for a consistent description of gravity as a non-perturbatively renormalizable quantum field theory. In this framework the gravitational interactions are encoded in a renormalization group flow connecting the quantum gravity regime at trans-Planckian scales to observable low-energy physics. Our proceedings reviews the key elements underlying the predictive power of the construction and summarizes the state-of-the-art in determining its free parameters. The explicit construction of a realistic renormalization group trajectory describing our world shows that the flow (...) possesses two characteristic scales. The Planck scale where Newton’s coupling G becomes constant is generated dynamically. The freeze-out of the cosmological constant \ occurs at a terrestrial scale fixed by the observed value of the dimensionless product \. We also review the perspectives of determining the free parameters of the theory through cosmologicalobservations. (shrink)

Smells are often said to be ineffable, and linguistic research shows that languages like English lack a dedicated olfactory lexicon. Starting from this evidence, I propose an account of how we talk about smells in English. Our reports about the way things smell are comparative: When we say that something smells burnt or like roses, we characterise the thing's smell by noting its similarity to the characteristic smells of certain odorous things (burnt things, roses). The account explains both the strengths (...) and limitations of our smell discourse, and has implications for philosophical discussions of the relation between language and appearances. (shrink)

Many take the lesson of the paradoxes to be that we ought to impose some form of logical revision. It is argued here that this kind of move should not be taken lightly.

1. Historically, our sense of smell has been deemed informationally impoverished, not very discerning, subjective, ineffable, and generally of little value (for an overview, see e.g., Barwich, 2020...